RISC Publications

The EGIR-RISC Study (The European group for the study of insulin resistance: relationship between insulin sensitivity and cardiovascular disease risk): I. Methodology and objectives
Hills SA, Balkau B, Coppack SW, Dekker JM, Mari A, Natali A, Walker M, Ferrannini E; EGIR-RISC Study Group.
Diabetologia 2004; 47: 566-570
Insulin resistance, insulin exposure, and waist circumference as indicators of metabolic risk: the RISC Study
Ferrannini E, Balkau B, Coppack SW, Dekker JM, Mari A, Nolan J, Walker M, Natali A, Beck-Nielsen H; RISC Investigators.
J Clin Endoc Metab 2007; 92: 2885-2892
Habitual physical activity and vascular aging in healthy young-to-middle aged population at low CV risk
Kozakova M, Palombo C, Mhamdi L, Konrad T, Nilsson P, Staehr PB, Paterni M, Balkau B; RISC Investigators.
Stroke. 2007; 38:2549-2555
Association of fasting glucagon and proinsulin concentrations with insulin resistance
Ferrannini E, Muscelli E, Natali A, Gabriel R, Mitrakou A, Flyvbjerg A, Golay A, Hojlund K; Relationship between Insulin Sensitivity and Cardiovascular Disease Risk (RISC) Project Investigators.
Diabetologia 2007; 50:2342-2347
Common variants of the novel type 2 diabetes genes CDKAL1 and HHEX/IDE are associated with decreased pancreatic beta-cell function.
Pascoe L, Tura A, Patel SK, Ibrahim IM, Ferrannini E, Zeggini E, Weedon MN, Mari A, Hattersley AT, McCarthy MI, Frayling TM, Walker M; RISC Consortium; U.K. Type 2 Diabetes Genetics Consortium.
Diabetes 2007;56:3101-3104.
Variation in the ADIPOQ gene promoter is associated with carotid intima media thickness independent of plasma adiponectin levels in healthy subjects
Patel S, Flyvbjerg A, Kozàkovà M, Frystyk J, Ibrahim IM, Petrie JR, Avery PJ, Ferrannini E, Walker M; RISC Investigators.
Eur Heart J 2008;29:386-393
Influence of the ACE gene I/D polymorphism on insulin sensitivity and impaired glucose tolerance in healthy subjects.
Bonnet F, Patel S, Laville M, Balkau B, Favuzzi A, Monti LD, Lalic N, Walker M; European Group for the Study of Insulin Resistance Relationship Between Insulin Sensitivity and Cardiovascular Disease Risk Study Group.
Diabetes Care 2008;31:789-794
Beta cell glucose sensitivity is decreased by 39% in healthy subjects carrying multiple diabetes risk alleles compared to those with no risk alleles
Pascoe L, Frayling TM, Weedon MN, Mari A, Tura A, Ferrannini E, Walker M; RISC Consortium.
Diabetologia 2008 ;51:1989-1992
Body composition and common carotid artery remodeling in a healthy population: US tissue characterization study
Kozakova M, Palombo C, Paterni M, Anderwald CH, Konrad T, Colgan MP, Flyvbjerg A, Dekker J; Relationship between Insulin Sensitivity Cardiovascular risk Investigators
J Clin Endocrinol Metab 2008;93:3325-3332
Physical Activity and Insulin Sensitivity. The RISC Study.
Balkau B, Mhamdi L, Oppert JM, Nolan J, Golay A, Porcellati F, Laakso M, Ferrannini E; EGIR-RISC Study Group.
Diabetes 2008 57(10):2613-8.
The Effect of Menopause on Carotid Artery Remodeling, Insulin Sensitivity, and Plasma Adiponectin in Healthy Women.
Muscelli E, Kozàkovà M, Flyvbjerg A, Kyriakopoulou K, Astiarraga BD, Glintborg D, Konrad T, Favuzzi A, Petrie J; RISC investigators.
Am J Hypertens 2009; 22:364-370
Fatty liver index is associated with insulin resistance, risk of coronary heart disease and early atherosclerosis in a healthy population.
Gastaldelli A, Kozakova M, Højlund K, Flyvbjerg A, Favuzzi A, Mitrakou A, Balkau B; The RISC Investigators.
Hepatology 2009 ;49:1537-1544
Low-grade chronic inflammation in the relationship between insulin sensitivity and cardiovascular disease (RISC) population: associations with insulin resistance and cardiometabolic risk profile.
de Rooij SR, Nijpels G, Nilsson PM, Nolan JJ, Gabriel R, Bobbioni-Harsch E, Mingrone G, Dekker JM; Relationship Between Insulin Sensitivity and Cardiovascular Disease (RISC) Investigators.
Diabetes Care 2009;32:1295-1301
Fasting insulin has a stronger association with an adverse cardio-metabolic risk profile than insulin resistance: The RISC study
de Rooij S, Dekker J, Kozakova M, Mitrakou A, Melander O, Gabriel R, Guidone C, Hojlund K, Murphy M, Nijpels G.
Eur J Endocrinol 2009;161:223-230
Common genetic variation in the melatonin receptor 1B gene (MTNR1B) is associated with decreased early-phase melatonin receptor 1B gene (MTNR1B) is associated with decreased early-phase insulin response
Langenberg C, Pascoe L, Mari A, Tura A, Laakso M, Frayling TM, Barroso I, Loos RJ, Wareham NJ, Walker M
Diabetologia 2009; 52:1537–1542
Correlation of the leptin: adiponectin ratio with measures of insulin resistance in non-diabetic individuals.
Finucane FM, Luan J, Wareham NJ, Sharp SJ, O'Rahilly S, Balkau B, Flyvbjerg A, Walker M, Højlund K, Nolan JJ
Diabetologia 2009;52:2345-2349
Metabolic characteristics of prehypertension: role of classification criteria and gender.
Natali A, Muscelli, E, Casolaro A, Nilsson P, Melander O, Lalic N, Ferrannini E, Petrie J
J Hyperten. 2009;27:2394-2402
Beta cell (dys)function in non-diabetic offspring of diabetic patients
Stadler M, Pacini G, Petrie J, Luger A, Anderwald C
Diabetologia 2009; 52:2435-2444
Fat distribution influences the cardio-metabolic profile in a clinically healthy European poulation
E. Bobbioni-Harsch, Z. Pataky, V. Makoundou, M. Kozakova, J. Dekker, A. Golay
Eur J Clin Invest 2009;39:1055-1064
Impaired β-cell glucose sensitivity rather than inadequate compensation for insulin resistance is the dominant defect in glucose intolerance
Mari A, Tura A, Natali A, Laville M, Laakso M, Gabriel R, Beck-Nielsen H, Ferrannini E; The RISC Investigators.
Diabetologia 2010;53:749-756
Impact of family history on relationships among insulin resistance, LDL cholesterol and carotid IMT in healthy adults
Anderwald C, Stadler M, Golay A, Krebs M, Petrie J, Luger A, and the RISC Investigators.
Heart 2010;96:1191-1200.
Effect of sedentary behaviour and vigorous physical activity on segment-specific carotid wall thickness and its progression in a healthy population.
Kozàkovà M, Palombo C, Morizzo C, Nolan JJ, Konrad T, Balkau B;
Eur Heart J 2010 ;31:1511-1519
One hour plasma glucose identifies insulin resistance and ß-cell dysfunction in individuals with normal glucose tolerance. Cross sectional data from the RISC study
Manco M, Panunzi S, MacFarlane D, Golay A, Melander O, Konrad T, Petrie J, Mingrone G
Diabetes Care 2010;33:2090-2097
α-hydroxybutyrate is an early biomarker of insulin resistance and glucose intolerance in a nondiabetic population.
Gall W, Beebe K, Lawton KA, Adam KP, Mitchell MW, Nakhle PJ, Ryals JA, Milburn MV, Nannipieri M, Camastra S, Natali A, Ferrannini E
PLoS ONE 2010; 5:e 10883
Detailed physiologic characterization reveals diverse mechanisms for novel genetic Loci regulating glucose and insulin metabolism in humans
Ingelsson E, Langenberg C, Hivert MF, Prokopenko I, Lyssenko V, Dupuis J, Mägi R, Sharp S, Jackson AU, Assimes TL, Shrader P, Knowles JW, Zethelius B, Abbasi FA, Bergman RN, Bergmann A, Berne C, Boehnke M, Bonnycastle LL, Bornstein SR, Buchanan TA, Bumpstead SJ, Böttcher Y, Chines P, Collins FS, Cooper CC, Dennison EM, Erdos MR, Ferrannini E, Fox CS, Graessler J, Hao K, Isomaa B, Jameson KA, Kovacs P, Kuusisto J, Laakso M, Ladenvall C, Mohlke KL, Morken MA, Narisu N, Nathan DM, Pascoe L, Payne F, Petrie JR, Sayer AA, Schwarz PE, Scott LJ, Stringham HM, Stumvoll M, Swift AJ, Syvänen AC, Tuomi T, Tuomilehto J, Tönjes A, Valle TT, Williams GH, Lind L, Barroso I, Quertermous T, Walker M, Wareham NJ, Meigs JB, McCarthy MI, Groop L, Watanabe RM, Florez JC; MAGIC investigators (2010)
Diabetes 2010;59:1266-1275
Genetic variation in GIPR influences the glucose and insulin responses to an oral glucose challenge.
Saxena R, Hivert MF, Langenberg C, Tanaka T, Pankow JS, Vollenweider P, Lyssenko V, Bouatia-Naji N, Dupuis J, Jackson AU, Kao WH, Li M, Glazer NL, Manning AK, Luan J, Stringham HM, Prokopenko I, Johnson T, Grarup N, Boesgaard TW, Lecoeur C, Shrader P, O'Connell J, Ingelsson E, Couper DJ, Rice K, Song K, Andreasen CH, Dina C, Köttgen A, Le Bacquer O, Pattou F, Taneera J, Steinthorsdottir V, Rybin D, Ardlie K, Sampson M, Qi L, van Hoek M, Weedon MN, Aulchenko YS, Voight BF, Grallert H, Balkau B, Bergman RN, Bielinski SJ, Bonnefond A, Bonnycastle LL, Borch-Johnsen K, Böttcher Y, Brunner E, Buchanan TA, Bumpstead SJ, Cavalcanti-Proença C, Charpentier G, Chen YD, Chines PS, Collins FS, Cornelis M, J Crawford G, Delplanque J, Doney A, Egan JM, Erdos MR, Firmann M, Forouhi NG, Fox CS, Goodarzi MO, Graessler J, Hingorani A, Isomaa B, Jørgensen T, Kivimaki M, Kovacs P, Krohn K, Kumari M, Lauritzen T, Lévy-Marchal C, Mayor V, McAteer JB, Meyre D, Mitchell BD, Mohlke KL, Morken MA, Narisu N, Palmer CN, Pakyz R, Pascoe L, Payne F, Pearson D, Rathmann W, Sandbaek A, Sayer AA, Scott LJ, Sharp SJ, Sijbrands E, Singleton A, Siscovick DS, Smith NL, Sparsø T, Swift AJ, Syddall H, Thorleifsson G, Tönjes A, Tuomi T, Tuomilehto J, Valle TT, Waeber G, Walley A, Waterworth DM, Zeggini E, Zhao JH; GIANT consortium; MAGIC investigators, Illig T, Wichmann HE, Wilson JF, van Duijn C, Hu FB, Morris AD, Frayling TM, Hattersley AT, Thorsteinsdottir U, Stefansson K, Nilsson P, Syvänen AC, Shuldiner AR, Walker M, Bornstein SR, Schwarz P, Williams GH, Nathan DM, Kuusisto J, Laakso M, Cooper C, Marmot M, Ferrucci L, Mooser V, Stumvoll M, Loos RJ, Altshuler D, Psaty BM, Rotter JI, Boerwinkle E, Hansen T, Pedersen O, Florez JC, McCarthy MI, Boehnke M, Barroso I, Sladek R, Froguel P, Meigs JB, Groop L, Wareham NJ, Watanabe RM.
Nat Genet 2010; 42:142-148
Insulin sensitivity and β-cell function in the offspring of type 2 diabetic patients: impact of line of inheritance
Natali A, Muscelli E, Mari A, Balkau B, Walker M, Tura A, Anderwald C, Golay A, Ferrannini E;
J Clin Endocrinol Metab 2010;95:4703-4711
Genetic evidence that raised sex hormone binding globulin (SHBG) levels reduce the risk of type 2 diabetes.
Perry JR, Weedon MN, Langenberg C, Jackson AU, Lyssenko V, Sparsø T, Thorleifsson G, Grallert H, Ferrucci L, Maggio M, Paolisso G, Walker M, Palmer CN, Payne F, Young E, Herder C, Narisu N, Morken MA, Bonnycastle LL, Owen KR, Shields B, Knight B, Bennett A, Groves CJ, Ruokonen A, Jarvelin MR, Pearson E, Pascoe L, Ferrannini E, Bornstein SR, Stringham HM, Scott LJ, Kuusisto J, Nilsson P, Neptin M, Gjesing AP, Pisinger C, Lauritzen T, Sandbaek A, Sampson M; MAGIC, Zeggini E, Lindgren CM, Steinthorsdottir V, Thorsteinsdottir U, Hansen T, Schwarz P, Illig T, Laakso M, Stefansson K, Morris AD, Groop L, Pedersen O, Boehnke M, Barroso I, Wareham NJ, Hattersley AT, McCarthy MI, Frayling TM
Hum Mol Genet 2010;19:535-544
A novel surrogate index for hepatic insulin resistance.
Vangipurapu J, Stančáková A, Kuulasmaa T, Paananen J, Kuusisto J, Ferrannini E, Laakso M
Diabetologia 2011;54:540-543
Metabolic normality in overweight and obese subjects. Which parameters? Which risks?
Pataky Z, Makoundou V, Nilsson P, Gabriel RS, Lalic K, Muscelli E, Casolaro A, Golay A, Bobbioni-Harsch E
Int J Obesity 2011;35:1208-1215
Liver enzymes are associated with hepatic insulin resistance, insulin secretion and glucagon concentration in healthy men and women
Bonnet F, Ducluzeau PH, Gastaldelli A, Laville M, Anderwald CH, Konrad T, Mari A, Balkau B; for the RISC Study Group
Diabetes 2011;60:1660-1667
Natural history and physiological determinants of changes in glucose tolerance in a non-diabetic population: the RISC Study
Ferrannini E, Natali A, Muscelli E, Nilsson PM, Golay A, Laakso M, Beck-Nielsen H, Mari A; on behalf of the RISC Investigators.
Diabetologia 2011;54:1507-1516
Gender-Specific Differences in Carotid Intima-Media Thickness and Its Progression over Three
Years: A Multicenter European Study
Kozakova M; Palombo C; Morizzo; Nolan J, Konrad T, Dekker J, Balkau B, Nilsson P.
Nutr Metab Cardiovasc Dis 2013;23:151-158
Body weight, not insulin sensitivity or secretion, may predict spontaneous weight changes in nondiabetic and pre-diabetic subjects: the RISC Study.
Rebelos E, Muscelli E, Natali A, Balkau B, Mingrone G, Piatti P, Konrad T, Mari A, Ferrannini E; for the RISC Study Investigators.
Diabetes 2011;60:1938-1945
Influence of hyperinsulinemia and insulin resistance on in vivo beta-cell function: their role in human beta-cell dysfunction
Mari A, Tura A, Natali A, Anderwald C, Balkau B, Lalic N, Walker M, Ferrannini e.
Diabetes 2011;60:3141-3147
Plasma sCD36 associates with markers of atherosclerosis, insulin resistance and fatty liver in a non-diabetic, generally healthy population
Handberg A, Højlund K, Gastaldelli A, Flyvbjerg A, Dekker JM, Petrie J, Piatti P, Beck-Nielsen H; the RISC Investigators.
J Int Med 2012;271:294-304
Glucokinase links krüppel-like factor 6 to the regulation of hepatic insulin sensitivity in non-alcoholic fatty liver disease.
Bechmann LP, Gastaldelli A, Vetter D, Patman GL, Pascoe L, Hannivoort RA, Lee UE, Fiel I, Muñoz U, Ciociaro D, Lee YM, Buzzigoli E, Miele L, Hui KY, Bugianesi E, Burt AD, Day CP, Mari A, Agius L, Walker M, Friedman SL, Reeves HL.
Hepatology 2012;55:1083-1093
From Metabolic Normality to Cardiometabolic Risk Factors in Subjects With Obesity
Bobbioni-Harsch E, Pataky Z, Makoundou V, Laville M, Disse E, Anderwald C, Konrad T, Golay A.
Obesity (Silver Spring) 2012;20:2063-9
Fatty liver index, gamma-glutamyltransferase, and early carotid plaques.
Kozakova M, Palombo C, Paterni Eng M, Dekker J, Flyvbjerg A, Mitrakou A, Gastaldelli A, Ferrannini E, ; and the RISC Investigators
Hepatology 2012; 55:1406-1415
Moderate alcohol consumption is associated with improved insulin sensitivity, reduced basal insulin secretion rate and lower fasting glucagon concentration in healthy women.
Bonnet F, Disse E, Laville M, Mari A, Hojlund K, Anderwald CH, Piatti P, Balkau B; for the RISC Study Group.
Diabetologia. 2012;55:3228-3237
Depressive symptoms, insulin sensitivity and insulin secretion in the RISC cohort study
Bot M, Pouwer F, De Jonge P, Nolan JJ, Mari A, Højlund K, Golay A, Balkau B, Dekker JM.
Diabetes Metab 2013;39:42-9
Impact of objectively measured sedentary behaviour on changes in insulin resistance and secretion over three years: interaction with weight gain. The RISC Study.
Lahjibi E, Heude B, Dekker JM, Hojlund K, Laville M, Nolan J, Oppert JM, Balkau B for the RISC group
Diabetes & Metabolism 2013;39:217-225
Early Metabolic Markers of the Development of Dysglycemia and Type 2 Diabetes and Their Physiological Significance
Ferrannini E, Natali A, Camastra S, Nannipieri M, Mari A, Adam KP, Milburn MV, Kastenmüller G, Adamski J, Tuomi T, Lyssenko V, Groop L, Gall W.
Diabetes 2013;62:1730-7.
Insulin sensitivity and carotid intima-media thickness: relationship between insulin sensitivity and cardiovascular risk study
Kozakova M, Natali A, Dekker J, Beck-Nielsen H, Laakso M, Nilsson P, Balkau B,
Arterioscler Thromb Vasc Biol 2013;33:1409-1417
Euglycaemic clamp insulin sensitivity and longitudinal systolic blood pressure: role of sex
Petrie JR, Malik MO, Balkau B, Perry CG, Højlund K, Pataky Z, Nolan J, Ferrannini, Natali A
Hypertension accepted
Genetic variants associated with glycine metabolism and their role in insulin sensitivity and type 2 diabetes.
Xie W, Wood AR, Lyssenko V, Weedon MN, Knowles JW, Alkayyali S, Assimes TL, Quertermous T, Abbasi F, Paananen J, Häring H, Hansen T, Pedersen O, Smith U, Laakso M, Dekker JM, Nolan JJ, Groop L, Ferrannini E, Adam KP, Gall WE, Frayling TM, Walker M.
Diabetes 2013;62:2141-2150
A novel fasting blood test for insulin resistance and prediabetes.
Cobb J, Gall W, Adam KP, Nakhle P, Button E, Hathorn J, Lawton K, Milburn M, Perichon R, Mitchell M, Natali A, Ferrannini E.
J Diabetes Sci Technol. 2013;7:100-10.
Fasting insulin at baseline influences the number of cardio-metabolic risk factors and the R-R interval at 3 years in a healthy population: the RISC study
Z. Pataky, A. Golay, M. Laville, E. Disse, A. Mitrakou, C. Guidone, R. Gabriel, E. Bobbioni-Harsch on behalf of the RISC Investigators
Diabetes & Metabolism 2013;39:330-6
Parental history of type 2 diabetes, TCF7L2 variant and lower insulin secretion are associated with incident hypertension.
Data from the DESIR and RISC cohorts.
Bonnet F, Roussel R, Natali A, Cauchi S, Petrie J, Laville M, Yengo L, Froguel P, Lange C, Lantieri O, Marre M, Balkau B, Ferrannini E; for the DESIR and RISC Study Groups.
Diabetologia 2013
Mendelian randomization studies do not support a causal role for reduced circulating adiponectin levels in insulin resistance and type 2 diabetes.
Yaghootkar H, Lamina C, Scott RA, Dastani Z, Hivert MF, Warren LL, Stancáková A, Buxbaum SG, Lyytikäinen LP, Henneman P, Wu Y, Cheung CY, Pankow JS, Jackson AU, Gustafsson S, Zhao JH, Ballantyne CM, Xie W, Bergman RN, Boehnke M, El Bouazzaoui F, Collins FS, Dunn SH, Dupuis J, Forouhi NG, Gillson C, Hattersley AT, Hong J, Kähönen M, Kuusisto J, Kedenko L, Kronenberg F, Doria A, Assimes TL, Ferrannini E, Hansen T, Hao K, Häring H, Knowles JW, Lindgren CM, Nolan JJ, Paananen J, Pedersen O, Quertermous T, Smith U; GENESIS Consortium; RISC Consortium, Lehtimäki T, Liu CT, Loos RJ, McCarthy MI, Morris AD, Vasan RS, Spector TD, Teslovich TM, Tuomilehto J, van Dijk KW, Viikari JS, Zhu N, Langenberg C, Ingelsson E, Semple RK, Sinaiko AR, Palmer CN, Walker M, Lam KS, Paulweber B, Mohlke KL, van Duijn C, Raitakari OT, Bidulescu A, Wareham NJ, Laakso M, Waterworth DM, Lawlor DA, Meigs JB, Richards JB, Frayling TM.
Diabetes 2013;62:3589-98
Influence of Apolipoproteins on the Association Between Lipids and Insulin Sensitivity: A cross-sectional analysis of the RISC Study
Baldi S, Bonnet F, Laville M, Morgantini C, Monti L, Hojlund K, Ferrannini E, Natali A; on behalf of the RISC investigators.
Diabetes Care. 2013;36:4125-4131
Insulin sensitivity and albuminuria: The RISC Study
Pilz S, Rutters F, Nijpels G, Stehouwer CDA, Højlund K, Nolan JJ, Balkau B, Dekker JM and the RISC investigators
Diabetes Care 2014;37:1597-1603
Common genetic variants highlight the role of insulin resistance and body fat distribution in type 2 diabetes, independently of obesity.
Scott RA, Fall T, Pasko D, Barker A, Sharp SJ, Arriola L, Balkau B, Barricarte A, Barroso I, Boeing H, Clavel-Chapelon F, Crowe FL, Dekker JM, Fagherazzi G, Ferraninini E, Forouhi NG, Franks PW, Gavrila D, Giedraitis V, Grioni S, Groop LC, Kaaks R, Key TJ, Kühn T, Lotta L, Nilsson PM, Overvad K, Palli D, Panico S, Quirós JR, Rolandsson O, Roswall N, Sacerdote C, Sala N, Sánchez MJ, Schulze MB, Siddiq A, Slimani N, Sluijs I, Spijkerman AM, Tjonneland A, Tumino R, van der ADL, Yaghootkar H; The RISC study group; The InterAct consortium, McCarthy MI, Semple RK, Riboli E, Walker M, Ingelsson E, Frayling TM, Savage DB, Langenberg C, Wareham NJ.
Diabetes 2014;63:4378- 4387
A novel test for IGT utilizing metabolite markers of glucose tolerance.
Cobb J, Eckhart A, Perichon R, Wulff J, Mitchell M, Adam KP, Wolfert R, Button E, Lawton K, Elverson R, Carr B, Sinnott M, Ferrannini E
J Diabetes Sci Technol 2015;9:69-76.
Identification and validation of N-acetyltransferase 2 as an insulin sensitivity gene.
Knowles JW, Xie W, Zhang Z, Chennemsetty I, Assimes TL, Paananen J, Hansson O, Pankow J, Goodarzi MO, Carcamo-Orive I, Morris AP, Chen YD, Mäkinen VP, Ganna A, Mahajan A, Guo X, Abbasi F, Greenawalt DM, Lum P, Molony C, Lind L, Lindgren C, Raffel LJ, Tsao PS, Schadt EE, Rotter JI, Sinaiko A, Reaven G, Yang X, Hsiung CA, Groop L, Cordell HJ, Laakso M, Hao K, Ingelsson E, Frayling TM, Weedon MN, Walker M, Quertermous T.
J Clin Invest 2015 Apr 1;125:1739-51.
Elevated heart rate predicts beta cell function in non-diabetic individuals: the RISC cohort
Bonnet F, Empana JP, Natali A, Monti L, Golay A, Lalic K, Dekker J, Mari A, Balkau B
Eur J Endocrinol 2015;173:409-415
Obesity and Carotid Artery Remodeling
Michaela Kozakova, Carlo Palombo, Carmela Morizzo, Kurt Højlund, Mensun Hatunic, Beverley Balkau, Peter Nilsson, and Ele Ferrannini
Nutrition and Diabetes 2015;173:409-415
Influence of endogenous NEFA on beta cell function in humans.
Rebelos E, Seghieri M, Natali A, Balkau B, Golay A, Piatti PM, Lalic NM, Laakso M, Mari A, Ferrannini E.
Diabetologia 2015;58:2344-51
Beta-cell function is associated with carotid intima-media thickness independently of insulin resistance, in healthy individuals
Roussel R, Natali A, Balkau B, Højlund K, Sánchez G, Nolan JJ, Mari A, Kozakova M, Bonnet F
J Hypertension 2016;34:685-91
The association between sleep duration, insulin sensitivity and beta-cell function: the EGIR-RISC study
Rutters F, Besson H, Walker M, Mari A, Konrad T, Nilsson PM, Balkau B, Dekker JM on behalf of the EGIR-RISC Study group
JCEM 2017;101:3272-3280
Insulin resistance and β-cell function in smokers – results from the EGIR-RISC European multicenter study
Gottsater M, Balkau B, Hatunic M, Gabriel R, Anderwald CH, Dekker J, Lalic N, Nilsson P
Diabetic Medicine accepted 2017;34:223-228
Shape of the OGTT glucose curve and risk of impaired glucose metabolism in the EGIR-RISC cohort
Manco M, Nolfe G, Pataky Z, Monti L, Porcellati F, Gabriel R, Mitrakou A, Mingrone G.
Metabolism 2017;70:42-50
Gamma-glutamyltransferase, fatty liver index and hepatic insulin resistance are associated with incident hypertension in two longitudinal studies.
Bonnet F, Gastaldelli A, Pihan-Le Bars F, Natali A, Roussel R, Petrie J, Tichet J, Marre M, Fromenty B, Balkau B; D.E.S.I.R., RISC Study Groups.
J Hypertens 2017;35:493-500.
Plasma HDL-cholesterol and triglycerides, but not LDL-cholesterol, are associated with insulin secretion in non-diabetic subjects.
Natali A, Baldi S, Bonnet F, Petrie J, Trifirò S, Tricò D, Mari A; RISC Investigators..
Metabolism. 2017;69:33-42
α-Hydroxybutyric Acid Is a Selective Metabolite Biomarker of Impaired Glucose Tolerance.
Cobb J, Eckhart A, Motsinger-Reif A, Carr B, Groop L, Ferrannini E.
Diabetes Care. 2016;39:988-95.
Identification of Novel Biomarkers to Monitor b-Cell Function and Enable Early Detection of Type 2 Diabetes Risk
Belongie KJ, Ferrannini E, Johnson K, Andrade-Gordon P, Hansen MK, Petrie JR.
PlosOne 2017;12:e1082932
High density lipoprotein with apolipoprotein C-III is associated with carotid intima-media thickness among generally healthy individuals.
Yamamoto R, Sacks FM, Hu FB, Rosner B, Furtado JD, Aroner SA, Ferrannini E, Baldi S, Kozakova M, Balkau B, Natali A, Jensen MK; RISC Investigators
Atherosclerosis 2018;269:92-99.
The relationship between bone turnover and insulin sensitivity and secretion: Cross-sectional and prospective data from the RISC cohort study
Frost M, Balkau B, Hatunic M, Konrad T, Mingrone G, Højlund K.
Bone 2018;108:98-105
Pathophysiological characteristics underlying different glucose response curves: a latent class trajectory analysis from the prospective EGIR-RISC study
Hulman A, Witte DR, Vistisen D, Balkau B, Dekker J, Herder C , Hatunic M, Konrad T, Færch K, Manco M
Diabetes Care 2018;41:1740-1748
Renal function markers and insulin sensitivity after 3 years in a healthy cohort, the EGIR-RISC Study
Siméon S, Massy Z, Højlund K, Lalic K, Porcellati F, Dekker J, Petrie J, Currie J, Balkau B
BMC Nephrology 2018;19:124
Modification and Validation of the Triglyceride-to-HDL Cholesterol Ratio as a Surrogate of Insulin Sensitivity in White Juveniles and Adults without Diabetes Mellitus: The Single Point Insulin Sensitivity Estimator (SPISE).
Paulmichl K, Hatunic M, Højlund K, Jotic A, Krebs M, Mitrakou A, Porcellati F, Tura A, Bergsten P, Forslund A, Manell H, Widhalm K, Weghuber D, Anderwald CH; Beta-JUDO Investigators; RISC Investigators
Clin Chem 2016;62:1211-9.
Associations between sleep duration and sleep debt with insulin sensitivity and insulin secretion in the EGIR-RISC Study.
van Dijk D, Balkau B, Segrestin B, Gottsäter M, Gabriel R, Hatunic M, Mari A, Dekker JM, Rutters F; EGIR-RISC Study Group.
Diabetes Metab 2018 Nov 12. pii: S1262-3636(18)30216-7. doi: 10.1016/j.diabet.2018.11.001. [Epub ahead of print]
One hour post-load plasma glucose and 3 year risk of worsening fasting and 2 hour glucose tolerance in the RISC cohort.
Manco M, Mari A, Petrie J, Mingrone G, Balkau B; EGIR-RISC study group.
Diabetologia 2019; 62: 544-548
Glucose Measurements at Various Time points during the OGTT and their role in caputuring glucose responses patterns
Hulman A, Wagner R, Vistisen D, Færch K, Balkau B, Manco M, Golay A, Häring HU, Heni M, Fritsche A, Witte DR.
Diabetes Care 2019;42:e56-e57
Differential methylation of the type 2 diabetes susceptibility locus KCNQ1 is associated with insulin sensitivity and is predicted by CpG site specific genetic variation.
Shah UJ, Xie W, Flyvbjerg A, Nolan JJ, Højlund K, Walker M, Relton CL, Elliott HR; RISC consortium.
Diabetes Res Clin Pract. 2019;148:189-199.
Identification, pathophysiology, and clinical implications of primary insulin hypersecretion in nondiabetic adults and adolescents.
Trico D, Natali A, Arslanian S, Mari A, Ferrannini E.
JCJCI Insight 2018;3(24)
Association analysis of 29,956 individuals confirms that a low-frequency variant at CCND2 halves the risk of type 2 diabetes by enhancing insulin secretion.
Yaghootkar H, Stancáková A, Freathy RM, Vangipurapu J, Weedon MN, Xie W, Wood AR, Ferrannini E, Mari A, Ring SM, Lawlor DA, Davey Smith G, Jørgensen T, Hansen T, Pedersen O, Steinthorsdottir V, Guðbjartsson DF, Thorleifsson G, Thorsteinsdottir U, Stefansson K, Hattersley AT, Walker M, Morris AD, McCarthy MI, Palmer CN, Laakso M, Frayling TM.
Diabetes 2015;64:2279-85.
A Genome-Wide Association Study of IVGTT-Based Measures of First-Phase Insulin Secretion Refines the Underlying Physiology of Type 2 Diabetes Variants.
Wood AR, Jonsson A, Jackson AU, Wang N, van Leewen N, Palmer ND, Kobes S, Deelen J, Boquete-Vilarino L, Paananen J, Stančáková A, Boomsma DI, de Geus EJC, Eekhoff EMW, Fritsche A, Kramer M, Nijpels G, Simonis-Bik A, van Haeften TW, Mahajan A, Boehnke M, Bergman RN, Tuomilehto J, Collins FS, Mohlke KL, Banasik K, Groves CJ, McCarthy MI; Diabetes Research on Patient Stratification (DIRECT), Pearson ER, Natali A, Mari A, Buchanan TA, Taylor KD, Xiang AH, Gjesing AP, Grarup N, Eiberg H, Pedersen O, Chen YD, Laakso M, Norris JM, Smith U, Wagenknecht LE, Baier L, Bowden DW, Hansen T, Walker M, Watanabe RM, 't Hart LM, Hanson RL, Frayling TM.
Diabetes 2017;66:2296-2309.
A central role for GRB10 in regulation of islet function in man.
Prokopenko I, Poon W, Mägi R, Prasad B R, Salehi SA, Almgren P, Osmark P, Bouatia-Naji N, Wierup N, Fall T, Stančáková A, Barker A, Lagou V, Osmond C, Xie W, Lahti J, Jackson AU, Cheng YC, Liu J, O'Connell JR, Blomstedt PA, Fadista J, Alkayyali S, Dayeh T, Ahlqvist E, Taneera J, Lecoeur C, Kumar A, Hansson O, Hansson K, Voight BF, Kang HM, Levy-Marchal C, Vatin V, Palotie A, Syvänen AC, Mari A, Weedon MN, Loos RJ, Ong KK, Nilsson P, Isomaa B, Tuomi T, Wareham NJ, Stumvoll M, Widen E, Lakka TA, Langenberg C, Tönjes A, Rauramaa R, Kuusisto J, Frayling TM, Froguel P, Walker M, Eriksson JG, Ling C, Kovacs P, Ingelsson E, McCarthy MI, Shuldiner AR, Silver KD, Laakso M, Groop L, Lyssenko V.
PLoS Genet. 2014;10:e1004235.
Genome-wide physical activity interactions in adiposity - A meta-analysis of 200,452 adults.
Graff M, Scott RA, Justice AE, Young KL, Feitosa MF, Barata L, Winkler TW, Chu AY, Mahajan A, Hadley D, Xue L, Workalemahu T, Heard-Costa NL, den Hoed M, Ahluwalia TS, Qi Q, Ngwa JS, Renström F, Quaye L, Eicher JD, Hayes JE, Cornelis M, Kutalik Z, Lim E, Luan J, Huffman JE, Zhang W, Zhao W, Griffin PJ, Haller T, Ahmad S, Marques-Vidal PM, Bien S, Yengo L, Teumer A, Smith AV, Kumari M, Harder MN, Justesen JM, Kleber ME, Hollensted M, Lohman K, Rivera NV, Whitfield JB, Zhao JH, Stringham HM, Lyytikäinen LP, Huppertz C, Willemsen G, Peyrot WJ, Wu Y, Kristiansson K, Demirkan A, Fornage M, Hassinen M, Bielak LF, Cadby G, Tanaka T, Mägi R, van der Most PJ, Jackson AU, Bragg-Gresham JL, Vitart V, Marten J, Navarro P, Bellis C, Pasko D, Johansson Å, Snitker S, Cheng YC, Eriksson J, Lim U, Aadahl M, Adair LS, Amin N, Balkau B, Auvinen J, Beilby J, Bergman RN, Bergmann S, Bertoni AG, Blangero J, Bonnefond A, Bonnycastle LL, Borja JB, Brage S, Busonero F, Buyske S, Campbell H, Chines PS, Collins FS, Corre T, Smith GD, Delgado GE, Dueker N, Dörr M, Ebeling T, Eiriksdottir G, Esko T, Faul JD, Fu M, Færch K, Gieger C, Gläser S, Gong J, Gordon-Larsen P, Grallert H, Grammer TB, Grarup N, van Grootheest G, Harald K, Hastie ND, Havulinna AS, Hernandez D, Hindorff L, Hocking LJ, Holmens OL, Holzapfel C, Hottenga JJ, Huang J, Huang T, Hui J, Huth C, Hutri-Kähönen N, James AL, Jansson JO, Jhun MA, Juonala M, Kinnunen L, Koistinen HA, Kolcic I, Komulainen P, Kuusisto J, Kvaløy K, Kähönen M, Lakka TA, Launer LJ, Lehne B, Lindgren CM, Lorentzon M, Luben R, Marre M, Milaneschi Y, Monda KL, Montgomery GW, De Moor MHM, Mulas A, Müller-Nurasyid M, Musk AW, Männikkö R, Männistö S, Narisu N, Nauck M, Nettleton JA, Nolte IM, Oldehinkel AJ, Olden M, Ong KK, Padmanabhan S, Paternoster L, Perez J, Perola M, Peters A, Peters U, Peyser PA, Prokopenko I, Puolijoki H, Raitakari OT, Rankinen T, Rasmussen-Torvik LJ, Rawal R, Ridker PM, Rose LM, Rudan I, Sarti C, Sarzynski MA, Savonen K, Scott WR, Sanna S, Shuldiner AR, Sidney S, Silbernagel G, Smith BH, Smith JA, Snieder H, Stančáková A, Sternfeld B, Swift AJ, Tammelin T, Tan ST, Thorand B, Thuillier D, Vandenput L, Vestergaard H, van Vliet-Ostaptchouk JV, Vohl MC, Völker U, Waeber G, Walker M, Wild S, Wong A, Wright AF, Zillikens MC, Zubair N, Haiman CA, Lemarchand L, Gyllensten U, Ohlsson C, Hofman A, Rivadeneira F, Uitterlinden AG, Pérusse L, Wilson JF, Hayward C, Polasek O, Cucca F, Hveem K, Hartman CA, Tönjes A, Bandinelli S, Palmer LJ, Kardia SLR, Rauramaa R, Sørensen TIA, Tuomilehto J, Salomaa V, Penninx BWJH, de Geus EJC, Boomsma DI, Lehtimäki T, Mangino M, Laakso M, Bouchard C, Martin NG, Kuh D, Liu Y, Linneberg A, März W, Strauch K, Kivimäki M, Harris TB, Gudnason V, Völzke H, Qi L, Järvelin MR, Chambers JC, Kooner JS, Froguel P, Kooperberg C, Vollenweider P, Hallmans G, Hansen T, Pedersen O, Metspalu A, Wareham NJ, Langenberg C, Weir DR, Porteous DJ, Boerwinkle E, Chasman DI; CHARGE Consortium; EPIC-InterAct Consortium; PAGE Consortium, Abecasis GR, Barroso I, McCarthy MI, Frayling TM, O'Connell JR, van Duijn CM, Boehnke M, Heid IM, Mohlke KL, Strachan DP, Fox CS, Liu CT, Hirschhorn JN, Klein RJ, Johnson AD, Borecki IB, Franks PW, North KE, Cupples LA, Loos RJF, Kilpeläinen TO.
PLoS Genet 2017 ;13:e1006528.
Large meta-analysis of genome-wide association studies identifies five loci for lean body mass.
Zillikens MC, Demissie S, Hsu YH, Yerges-Armstrong LM, Chou WC, Stolk L, Livshits G, Broer L, Johnson T, Koller DL, Kutalik Z, Luan J, Malkin I, Ried JS, Smith AV, Thorleifsson G, Vandenput L, Hua Zhao J, Zhang W, Aghdassi A, Åkesson K, Amin N, Baier LJ, Barroso I, Bennett DA, Bertram L, Biffar R, Bochud M, Boehnke M, Borecki IB, Buchman AS, Byberg L, Campbell H, Campos Obanda N, Cauley JA, Cawthon PM, Cederberg H, Chen Z, Cho NH, Jin Choi H, Claussnitzer M, Collins F, Cummings SR, De Jager PL, Demuth I, Dhonukshe-Rutten RAM, Diatchenko L, Eiriksdottir G, Enneman AW, Erdos M, Eriksson JG, Eriksson J, Estrada K, Evans DS, Feitosa MF, Fu M, Garcia M, Gieger C, Girke T, Glazer NL, Grallert H, Grewal J, Han BG, Hanson RL, Hayward C, Hofman A, Hoffman EP, Homuth G, Hsueh WC, Hubal MJ, Hubbard A, Huffman KM, Husted LB, Illig T, Ingelsson E, Ittermann T, Jansson JO, Jordan JM, Jula A, Karlsson M, Khaw KT, Kilpeläinen TO, Klopp N, Kloth JSL, Koistinen HA, Kraus WE, Kritchevsky S, Kuulasmaa T, Kuusisto J, Laakso M, Lahti J, Lang T, Langdahl BL, Launer LJ, Lee JY, Lerch MM, Lewis JR, Lind L, Lindgren C, Liu Y, Liu T, Liu Y, Ljunggren Ö, Lorentzon M, Luben RN, Maixner W, McGuigan FE, Medina-Gomez C, Meitinger T, Melhus H, Mellström D, Melov S, Michaëlsson K, Mitchell BD, Morris AP, Mosekilde L, Newman A, Nielson CM, O'Connell JR, Oostra BA, Orwoll ES, Palotie A, Parker SCJ, Peacock M, Perola M, Peters A, Polasek O, Prince RL, Räikkönen K, Ralston SH, Ripatti S, Robbins JA, Rotter JI, Rudan I, Salomaa V, Satterfield S, Schadt EE, Schipf S, Scott L, Sehmi J, Shen J, Soo Shin C, Sigurdsson G, Smith S, Soranzo N, Stančáková A, Steinhagen-Thiessen E, Streeten EA, Styrkarsdottir U, Swart KMA, Tan ST, Tarnopolsky MA, Thompson P, Thomson CA, Thorsteinsdottir U, Tikkanen E, Tranah GJ, Tuomilehto J, van Schoor NM, Verma A, Vollenweider P, Völzke H, Wactawski-Wende J, Walker M, Weedon MN, Welch R, Wichmann HE, Widen E, Williams FMK, Wilson JF, Wright NC, Xie W, Yu L, Zhou Y, Chambers JC, Döring A, van Duijn CM, Econs MJ, Gudnason V, Kooner JS, Psaty BM, Spector TD, Stefansson K, Rivadeneira F, Uitterlinden AG, Wareham NJ, Ossowski V, Waterworth D, Loos RJF, Karasik D, Harris TB, Ohlsson C, Kiel DP.
Nat Commun 2017;8:80.
New genetic loci link adipose and insulin biology to body fat distribution.
Shungin D, Winkler TW, Croteau-Chonka DC, Ferreira T, Locke AE, Mägi R, Strawbridge RJ, Pers TH, Fischer K, Justice AE, Workalemahu T, Wu JMW, Buchkovich ML, Heard-Costa NL, Roman TS, Drong AW, Song C, Gustafsson S, Day FR, Esko T, all T, Kutalik Z, Luan J, Randall JC, Scherag A, Vedantam S, Wood AR, Chen J, Fehrmann R, Karjalainen J, Kahali B, Liu CT, Schmidt EM, Absher D, Amin N, Anderson D, Beekman M, Bragg-Gresham JL, Buyske S, Demirkan A, Ehret GB, Feitosa MF, Goel A, Jackson AU, Johnson T, Kleber ME, Kristiansson K, Mangino M, Leach IM, Medina-Gomez C, Palmer CD, Pasko D, Pechlivanis S, Peters MJ, Prokopenko I, Stančáková A, Sung YJ, Tanaka T, Teumer A, Van Vliet-Ostaptchouk JV, Yengo L, Zhang W, Albrecht E, Ärnlöv J, Arscott GM, Bandinelli S, Barrett A, Bellis C, Bennett AJ, Berne C, Blüher M, Böhringer S, Bonnet F, Böttcher Y, Bruinenberg M, Carba DB, Caspersen IH, Clarke R, Daw EW, Deelen J, Deelman E, Delgado G, Doney AS, Eklund N, Erdos MR, Estrada K, Eury E, Friedrich N, Garcia ME, Giedraitis V, Gigante B, Go AS, Golay A, Grallert H, Grammer TB, Gräßler J, Grewal J, Groves CJ, Haller T, Hallmans G, Hartman CA, Hassinen M, Hayward C, Heikkilä K, Herzig KH, Helmer Q, Hillege HL, Holmen O, Hunt SC, Isaacs A, Ittermann T, James AL, Johansson I, Juliusdottir T, Kalafati IP, Kinnunen L, Koenig W, Kooner IK, Kratzer W, Lamina C, Leander K, Lee NR, Lichtner P, Lind L, Lindström J, Lobbens S, Lorentzon M, Mach F, Magnusson PK, Mahajan A, McArdle WL, Menni C, Merger S, Mihailov E, Milani L, Mills R, Moayyeri A, Monda KL, Mooijaart SP, Mühleisen TW, Mulas A, Müller G, Müller-Nurasyid M, Nagaraja R, Nalls MA, Narisu N, Glorioso N, Nolte IM, Olden M, Rayner NW, Renstrom F, Ried JS, Robertson NR, Rose LM, Sanna S, Scharnagl H, Scholtens S, Sennblad B, Seufferlein T, Sitlani CM, Smith AV, Stirrups K, Stringham HM, Sundström J, Swertz MA, Swift AJ, Syvänen AC, Tayo BO, Thorand B, Thorleifsson G, Tomaschitz A, Troffa C, van Oort FV, Verweij N, Vonk JM, Waite LL, Wennauer R, Wilsgaard T, Wojczynski MK, Wong A, Zhang Q, Zhao JH, Brennan EP, Choi M, Eriksson P, Folkersen L, Franco-Cereceda A, Gharavi AG, Hedman ÅK, Hivert MF, Huang J, Kanoni S, Karpe F, Keildson S, Kiryluk K, Liang L, Lifton RP, Ma B, McKnight AJ, McPherson R, Metspalu A, Min JL, Moffatt MF, Montgomery GW, Murabito JM, Nicholson G, Nyholt DR, Olsson C, Perry JR, Reinmaa E, Salem RM, Sandholm N, Schadt EE, Scott RA, Stolk L, Vallejo EE, Westra HJ, Zondervan KT; ADIPOGen Consortium; CARDIOGRAMplusC4D Consortium; CKDGen Consortium; GEFOS Consortium; GENIE Consortium; GLGC; ICBP; International Endogene Consortium; LifeLines Cohort Study; MAGIC Investigators; MuTHER Consortium; PAGE Consortium; ReproGen Consortium, Amouyel P, Arveiler D, Bakker SJ, Beilby J, Bergman RN, Blangero J, Brown MJ, Burnier M, Campbell H, Chakravarti A, Chines PS, Claudi-Boehm S, Collins FS, Crawford DC, Danesh J, de Faire U, de Geus EJ, Dörr M, Erbel R, Eriksson JG, Farrall M, Ferrannini E, Ferrières J, Forouhi NG, Forrester T, Franco OH, Gansevoort RT, Gieger C, Gudnason V, Haiman CA, Harris TB, Hattersley AT, Heliövaara M, Hicks AA, Hingorani AD, Hoffmann W, Hofman A, Homuth G, Humphries SE, Hyppönen E, Illig T, Jarvelin MR, Johansen B, Jousilahti P, Jula AM, Kaprio J, Kee F, Keinanen-Kiukaanniemi SM, Kooner JS, Kooperberg C, Kovacs P, Kraja AT, Kumari M, Kuulasmaa K, Kuusisto J, Lakka TA, Langenberg C, Le Marchand L, Lehtimäki T, Lyssenko V, Männistö S, Marette A, Matise TC, McKenzie CA, McKnight B, Musk AW, Möhlenkamp S, Morris AD, Nelis M, Ohlsson C, Oldehinkel AJ, Ong KK, Palmer LJ, Penninx BW, Peters A, Pramstaller PP, Raitakari OT, Rankinen T, Rao DC, Rice TK, Ridker PM, Ritchie MD, Rudan I, Salomaa V, Samani NJ, Saramies J, Sarzynski MA, Schwarz PE, Shuldiner AR, Staessen JA, Steinthorsdottir V, Stolk RP, Strauch K, Tönjes A, Tremblay A, Tremoli E, Vohl MC, Völker U, Vollenweider P, Wilson JF, Witteman JC, Adair LS, Bochud M, Boehm BO, Bornstein SR, Bouchard C, Cauchi S, Caulfield MJ, Chambers JC, Chasman DI, Cooper RS, Dedoussis G, Ferrucci L, Froguel P, Grabe HJ, Hamsten A, Hui J, Hveem K, Jöckel KH, Kivimaki M, Kuh D, Laakso M, Liu Y, März W, Munroe PB, Njølstad I, Oostra BA, Palmer CN, Pedersen NL, Perola M, Pérusse L, Peters U, Power C, Quertermous T, Rauramaa R, Rivadeneira F, Saaristo TE, Saleheen D, Sinisalo J, Slagboom PE, Snieder H, Spector TD, Stefansson K, Stumvoll M, Tuomilehto J, Uitterlinden AG, Uusitupa M, van der Harst P, Veronesi G, Walker M, Wareham NJ, Watkins H, Wichmann HE, Abecasis GR, Assimes TL, Berndt SI, Boehnke M, Borecki IB, Deloukas P, Franke L, Frayling TM, Groop LC, Hunter DJ, Kaplan RC, O'Connell JR, Qi L, Schlessinger D, Strachan DP, Thorsteinsdottir U, van Duijn CM, Willer CJ, Visscher PM, Yang J, Hirschhorn JN, Zillikens MC, McCarthy MI, Speliotes EK, North KE, Fox CS, Barroso I, Franks PW, Ingelsson E, Heid IM, Loos RJ, Cupples LA, Morris AP, Lindgren CM, Mohlke KL. Stefansson K, Stumvoll M, Tuomilehto J, Uitterlinden AG, Uusitupa M, van der Harst P, Veronesi G, Walker M, Wareham NJ, Watkins H, Wichmann HE, Abecasis GR, Assimes TL, Berndt SI, Boehnke M, Borecki IB, Deloukas P, Franke L, Frayling TM, Groop LC, Hunter DJ, Kaplan RC, O'Connell JR, Qi L, Schlessinger D, Strachan DP, Thorsteinsdottir U, van Duijn CM, Willer CJ, Visscher PM, Yang J, Hirschhorn JN, Zillikens MC, McCarthy MI, Speliotes EK, North KE, Fox CS, Barroso I, Franks PW, Ingelsson E, Heid IM, Loos RJ, Cupples LA, Morris AP, Lindgren CM, Mohlke KL.
Nature 2015;518:187-196
Genome-wide meta-analysis uncovers novel loci influencing circulating leptin levels.
Kilpeläinen TO, Carli JF, Skowronski AA, Sun Q, Kriebel J, Feitosa MF, Hedman ÅK, Drong AW, Hayes JE, Zhao J, Pers TH, Schick U, Grarup N, Kutalik Z, Trompet S, Mangino M, Kristiansson K, Beekman M, Lyytikäinen LP, Eriksson J, Henneman P, Lahti J, Tanaka T, Luan J, Del Greco M F, Pasko D, Renström F, Willems SM, Mahajan A, Rose LM, Guo X, Liu Y, Kleber ME, Pérusse L, Gaunt T, Ahluwalia TS, Ju Sung Y, Ramos YF, Amin N, Amuzu A, Barroso I, Bellis C, Blangero J, Buckley BM, Böhringer S, I Chen YD, de Craen AJ, Crosslin DR, Dale CE, Dastani Z, Day FR, Deelen J, Delgado GE, Demirkan A, Finucane FM, Ford I, Garcia ME, Gieger C, Gustafsson S, Hallmans G, Hankinson SE, Havulinna AS, Herder C, Hernandez D, Hicks AA, Hunter DJ, Illig T, Ingelsson E, Ioan-Facsinay A, Jansson JO, Jenny NS, Jørgensen ME, Jørgensen T, Karlsson M, Koenig W, Kraft P, Kwekkeboom J, Laatikainen T, Ladwig KH, LeDuc CA, Lowe G, Lu Y, Marques-Vidal P, Meisinger C, Menni C, Morris AP, Myers RH, Männistö S, Nalls MA, Paternoster L, Peters A, Pradhan AD, Rankinen T, Rasmussen-Torvik LJ, Rathmann W, Rice TK, Brent Richards J, Ridker PM, Sattar N, Savage DB, Söderberg S, Timpson NJ, Vandenput L, van Heemst D, Uh HW, Vohl MC, Walker M, Wichmann HE, Widén E, Wood AR, Yao J, Zeller T, Zhang Y, Meulenbelt I, Kloppenburg M, Astrup A, Sørensen TI, Sarzynski MA, Rao DC, Jousilahti P, Vartiainen E, Hofman A, Rivadeneira F, Uitterlinden AG, Kajantie E, Osmond C, Palotie A, Eriksson JG, Heliövaara M, Knekt PB, Koskinen S, Jula A, Perola M, Huupponen RK, Viikari JS, Kähönen M, Lehtimäki T, Raitakari OT, Mellström D, Lorentzon M, Casas JP, Bandinelli S, März W, Isaacs A, van Dijk KW, van Duijn CM, Harris TB, Bouchard C, Allison MA, Chasman DI, Ohlsson C, Lind L, Scott RA, Langenberg C, Wareham NJ, Ferrucci L, Frayling TM, Pramstaller PP, Borecki IB, Waterworth DM, Bergmann S, Waeber G, Vollenweider P, Vestergaard H, Hansen T, Pedersen O, Hu FB, Eline Slagboom P, Grallert H, Spector TD, Jukema JW, Klein RJ, Schadt EE, Franks PW, Lindgren CM, Leibel RL, Loos RJ.
Nat Commun 2016;7:10494.
Discovery of biomarkers for glycaemic deterioration before and after the onset of type 2 diabetes: descriptive characteristics of the epidemiological studies within the IMI DIRECT Consortium.
Koivula RW, Forgie IM, Kurbasic A, Viñuela A, Heggie A, Giordano GN, Hansen TH, Hudson M, Koopman ADM, Rutters F, Siloaho M, Allin KH, Brage S, Brorsson CA, Dawed AY, De Masi F, Groves CJ, Kokkola T, Mahajan A, Perry MH, Rauh SP, Ridderstråle M, Teare HJA, Thomas EL, Tura A, Vestergaard H, White T, Adamski J, Bell JD, Beulens JW, Brunak S, Dermitzakis ET, Froguel P, Frost G, Gupta R, Hansen T, Hattersley A, Jablonka B, Kaye J, Laakso M, McDonald TJ, Pedersen O, Schwenk JM, Pavo I, Mari A, McCarthy MI, Ruetten H, Walker M, Pearson E, Franks PW; IMI DIRECT Consortium.
Diabetologia. 2019 Jun 15.
Circulating palmitoleic acid is an independent determinant of insulin sensitivity, β-cell function and glucose tolerance in non-diabetic individuals: a longitudinal analysis.
Tricò D, Mengozzi A, Nesti L, Hatunic M, Gabriel Sanchez R, Konrad T, Lalić K, Lalić NM, Mari A, Natali A; EGIR-RISC Study Group.
Diabetologia. 2020 Jan;63(1):206-218.
Gamma-glutamyltransferase, arterial remodeling and prehypertension in a healthy population at low cardiometabolic risk
Kozakova M, Gastaldelli A, Morizzo C, Højlund K, Nilssson PM, Ferrannini E; RISC Investigators, Palombo C.
J Hum Hypertens 2020 Apr 29
Discovery of biomarkers for glycaemic deterioration before and after the onset of type 2 diabetes: descriptive characteristics of the epidemiological studies within the IMI DIRECT Consortium.
Koivula RW, Forgie IM, Kurbasic A, Viñuela A, Heggie A, Giordano GN, Hansen TH, Hudson M, Koopman ADM, Rutters F, Siloaho M, Allin KH, Brage S, Brorsson CA, Dawed AY, De Masi F, Groves CJ, Kokkola T, Mahajan A, Perry MH, Rauh SP, Ridderstråle M, Teare HJA, Thomas EL, Tura A, Vestergaard H, White T, Adamski J, Bell JD, Beulens JW, Brunak S, Dermitzakis ET, Froguel P, Frost G, Gupta R, Hansen T, Hattersley A, Jablonka B, Kaye J, Laakso M, McDonald TJ, Pedersen O, Schwenk JM, Pavo I, Mari A, McCarthy MI, Ruetten H, Walker M, Pearson E, Franks PW; IMI DIRECT Consortium.
Diabetologia 2019;62:1601-1615.
Disruption of fasting and post-load glucose homeostasis are largely independent and sustained by distinct and early major beta-cell function defects: a cross-sectional and longitudinal analysis of the Relationship between Insulin Sensitivity and Cardiovascular risk (RISC) study cohort.
Mengozzi A, Tricò D, Nesti L, Petrie J, Højlund K, Mitrakou A, Krebs M, Mari A, Natali A; RISC Investigators.
Metabolism 2020;105:154185.